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Pleximmune

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Plexision’s first patented product, the PleximmuneTM test, predicts the risk of acute cellular rejection after liver or intestine transplantation in children. Cellular rejection, the leading type of rejection after organ transplantation, is mediated by cell-mediated toxicity toward transplanted organs.

The PleximmuneTM test:

  • Is a functional test, which simulates the host-graft interaction.
  • Measures the inflammatory response of T-cytotoxic memory lymphocytes to donor cells. T-cytotoxic memory lymphocytes are a type of lymphocyte. Lymphocytes are a type of white blood cell.
  • Generates a numeric score called the immunoreactivity index. This index is compared with a rejection-risk threshold developed from testing of over 200 liver or intestine recipients to assign risk.