Rohan et al at the Medical University of South Carolina in Charleston, SC, recently evaluated the first 22 renal transplant recipients to receive clinical immune monitoring with donor-reactive T-cytotoxic memory cells. This cell type determines the likelihood of rejection in the Pleximark test. Increased donor-reactivity was associated with renal allograft rejection with a sensitivity of 83% and a negative predictive value of 91%. This increased reactivity also correlated with (r=0.453, p=0.03) with graft dysfunction measured with serum creatinine…....

Reference: Rohan VS, Soliman KM, Alqassieh A, Alkhader D, Pate N, Nadig SN. Renal allograft surveillance with allospecific T-cytotoxic memory cells. Ren Fail. 2020 Nov;42(1):1152-1156. doi: 10.1080/0886022X.2020.1846054. PMID: 33203287.