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Predicting Cellular Rejection With a Cell-Based Assay: Preclinical Evaluation in Children

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Allospecific CD154+T-cytotoxic memory cells (CD154+TcM) predict acute cellular rejection after liver transplantation (LTx) or intestine transplantation (ITx) in small cohorts of children and can enhance immunosuppression management, but await validation and clinical implementation.
To establish safety and probable benefit, CD154+TcM were measured in cryopreserved samples from 214 children younger than 21 years (National Clinical Trial 1163578). Training set samples (n = 158) were tested with research-grade reagents and 122 independent validation set samples were tested with current good manufacturing practices-manufactured reagents after assay standardization and reproducibility testing.
 
For details check the detailed publication.

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Predicting Cellular Rejection With a Cell-Based Assay: Preclinical Evaluation in Children | Plexision

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